Mechanisms of drug-induced liver injury: from bedside to bench

The mechanisms of drug-induced liver injury (DILI) are not well understood. In this Review, the authors propose that a bedside to bench approach involving the study of clinicopathological features of patients with DILI can provide insight into the mechanisms underlying this condition. The authors also discuss the potential role of several factors, including mitochondrial toxicity and the host immune system, in the etiopathogenesis of DILI.