Molecular imaging of advanced thyroid cancer: iodinated radiotracers and beyond

被引：0
|
作者：
Prasanna Santhanam
Lilja B. Solnes
Steven P. Rowe
机构：
[1] Johns Hopkins University School of Medicine,Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine
[2] Johns Hopkins University School of Medicine,Section of Nuclear Medicine, Department of Radiology and Radiological Science
来源：
Medical Oncology | 2017年 / 34卷
关键词：
Differentiated Thyroid Cancer; Radiotracers; Imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An important aspect of differentiated thyroid cancer (DTC) management is disease localization by imaging. Functional imaging of thyroid cancer with iodinated radiotracers has been employed for metastatic disease detection for long. More recently, 2-deoxy-2-[18F] fluoro-d-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), a non-iodinated ubiquitous PET tracer, has been used to detect non-radioiodine (RAI) avid disease. Advances in molecular imaging have led to the development of newer tracers like 18F-TFB (18F-tetrafluoroborate) that are transported through the sodium–iodide symporter (NIS) as well as 68 Ga-DOTATATE that image the somatostatin receptors sub-type 2 expressed in medullary thyroid cancer and some DTC. In coming years, there will be focus on newer receptor targets like prostate-specific membrane antigen expression and endoradiotherapies and theranostics.
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