The emerging role of RNA N6-methyladenosine methylation in breast cancer

被引：0
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作者：
Fangchao Zheng
Feng Du
Jiuda Zhao
Xue Wang
Yiran Si
Peng Jin
Haili Qian
Binghe Xu
Peng Yuan
机构：
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[2] Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The VIPII Gastrointestinal Cancer Division of Medical Department
[3] Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University,Breast Disease Diagnosis and Treatment Center
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of VIP Medical Services, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[5] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Surgery, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital
[6] Chinese Academy of Medical Sciences and Peking Union Medical College,State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute
来源：
Biomarker Research | / 9卷
关键词：
RNA methylation; Breast cancer; Clinicopathological features; Prognosis; Drug target;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.
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