Integrating insulin secretion and ER stress in pancreatic β-cells

被引：0

作者：

Katleen Lemaire

Frans Schuit

机构：

[1] Katleen Lemaire and Frans Schuit are in the Gene Expression Unit,Department of Molecular and Cellular Medicine

[2] KU Leuven,undefined

[3] Herestraat 49,undefined

[4] 3000 Leuven,undefined

[5] Belgium,undefined

来源：

Nature Cell Biology | 2012年 / 14卷

关键词：

D O I：

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学科分类号：

摘要：

After food consumption, insulin-secreting pancreatic β-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release — revealing a molecular point of convergence between the ER stress and insulin release pathways.

引用

页码：979 / 981

页数：2

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