Autophagy without conjugation

被引：0
|
作者：
Varnesh Tiku
Ivan Dikic
机构：
[1] Genentech,Department of Infectious Diseases
[2] Goethe University Frankfurt–Medical Faculty,Institute of Biochemistry II
[3] University Hospital,undefined
来源：
Nature Structural & Molecular Biology | 2019年 / 26卷
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学科分类号：
摘要：
Ubiquitin and ubiquitin-like proteins (UBLs) are essential regulators of a multitude of cellular processes, including autophagy. It is known that these proteins relay their effects by covalently modifying their substrate molecules. As an exception to this norm, Pang et al. report a novel phenomenon in which the UBL ATG12 interacts with its substrate ATG5 in a non-covalent fashion to promote autophagy in apicomplexan parasites and some yeasts.
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页码：249 / 250
页数：1
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