Recent Development of Two-Dimensional Liquid Chromatography in Food Analysis

Rapid, non-destructive, and high-throughput analytical methods for samples with complex matrices play an important role in food analysis. Two-dimensional liquid chromatography (2D-LC) is a suitable technique for the efficient separation and sensitive detection of non-volatile organic compounds. It has the characteristics of fast response, high sensitivity, and simple operation. This paper briefly introduces the working principle of 2D-LC, and the research and application in different food analysis by 2D-LC in recent years were reviewed. Against this background, the following conclusions are summarized: 2D-LC can be a powerful tool for the analysis of various food components. Its combination with mass spectrum (MS) contributes to establishing a relatively complete database to achieve the rapid, sensitive, and automatic characterization, which would be the future trend for food analysis.