Immunochemical Determination of Diclofenac in Tablets, Artificial Urine, and Surface Water Using Ruthenium and Rhenium Complexes

被引:0
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作者
E. P. Medyantseva
E. R. Gazizullina
D. V. Brusnitsyn
S. V. Fedorenko
A. R. Mustafina
K. A. Brylev
S. A. Eremin
O. A. Makhmudova
V. N. Khaziakhmetova
机构
[1] Butlerov Institute of Chemistry,
[2] Kazan (Volga Region) Federal University,undefined
[3] Arbuzov Institute of Organic and Physical Chemistry,undefined
[4] Federal Research Center Kazan Scientific Center,undefined
[5] Russian Academy of Sciences,undefined
[6] Nikolaev Institute of Inorganic Chemistry,undefined
[7] Siberian Branch,undefined
[8] Russian Academy of Sciences,undefined
[9] Lomonosov Moscow State University,undefined
[10] Faculty of Chemistry,undefined
[11] Institute of Fundamental Medicine and Biology,undefined
[12] Kazan (Volga Region) Federal University,undefined
来源
关键词
fluorescence polarization immunoassay; ruthenium silicate nanoparticles; immunosensor; rhenium clusters; diclofenac;
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学科分类号
摘要
Methods using fluorescence polarization analysis and an amperometric immunosensor for the immunochemical determination of the non-steroidal anti-inflammatory drug diclofenac in drugs, artificial urine, and surface water are proposed. High analytical sensitivity was achieved by using promising nanomaterials, in particular, silicon nanoparticles doped with highly luminescent ruthenium complexes and electrochemically active hexarhenium cluster complexes. The relative standard deviation was (0.070. It was shown that the developed procedures for immunochemical determination of diclofenac had a wider range of determined concentrations than other methods.
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页码:573 / 577
页数:4
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