Effect of CYP2C19, UGT1A8, and UGT2B7 on valproic acid clearance in children with epilepsy: a population pharmacokinetic model

被引：0
|
作者：
Shenghui Mei
Weixing Feng
Leting Zhu
Xingang Li
Yazhen Yu
Weili Yang
Baoqin Gao
Xiaojuan Wu
Fang Fang
Zhigang Zhao
机构：
[1] Capital Medical University,Department of Pharmacy, Beijing Tiantan Hospital
[2] Capital Medical University,Department of Clinical Pharmacology, College of Pharmaceutical Sciences
[3] Capital Medical University,Department of Neurology, Beijing Children’s Hospital
[4] Capital Medical University,Department of Pediatrics, Beijing Tiantan Hospital
来源：
European Journal of Clinical Pharmacology | 2018年 / 74卷
关键词：
Valproic acid; Uridine diphosphate glucuronosyltransferase; Cytochrome P450 family 2 subfamily C member 19; Clearance; Children; Population pharmacokinetic model; Nonlinear mixed-effects modeling;
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学科分类号：
摘要：
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页码：1029 / 1036
页数：7
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