Synthesis of 3-Diaminomethylene-2(3H)-furanones by Reaction of 2-Amino-4,5-dihydro-3-furancarboxamides with Amines

被引：0
|
作者：
Kenji Yamagata
Fumi Okabe
Motoyoshi Yamazaki
Yoshinobu Tagawa
机构：
[1] Faculty of Pharmaceutical Sciences,
[2] Fukuoka University,undefined
[3] 814-0180 Fukuoka,undefined
[4] Japan,undefined
来源：
Monatshefte für Chemie / Chemical Monthly | 2002年 / 133卷
关键词：
Keywords. Furancarboxamides; Furanones; Amines; Michael addition; Recyclization.;
D O I：
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摘要：
 The reaction of 2-amino-4,5-dihydro-3-furancarboxamides with morpholine in the presence of acetic acid in pyridine or under the influence of ammonium acetate gave the corresponding 3-diaminomethylene-4,5-dihydro-2(3H )-furanones; 4,5-dihydro-2-morpholino-3-furancarboxamides were not isolated. One of the former reacted with benzylamine to give (E )- and (Z )-3-(amino-(benzylamino)-methylene)-4,5-dihydro-4-phenyl-2(3H )-furanones and 2-benzylamino-4,5-dihydro-4-phenyl-3-furancarboxamide.
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页码：643 / 651
页数：8
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