Compounds Extracted from Phyllantus and Jatropha elliptica Inhibit the Binding of [3H]Glutamate and [3H]GMP-PNP in Rat Cerebral Cortex Membrane

被引：0

作者：

Lúcia H. Martini

Carla R. Souza

Patricia B. Marques

João B. Calixto

Rosendo A. Yunes

Diogo O. Souza

机构：

[1] Universidade Federal do Rio Grande do Sul,Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde

[2] Departamentos de Farmacologia,Química

[3] Universidade Federal de Santa Catarina,Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde

[4] Florianópolis,undefined

[5] Universidade Federal do Rio Grande do Sul,undefined

来源：

Neurochemical Research | 2000年 / 25卷

关键词：

Glutamate; guanine nucleotides; antinoception; naturally-occurring compounds;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Glutamate is to be considered a nociceptive neurotransmitter and glutamatergic antagonists present antinoceptive activity. In this study we investigated the effects of the naturally occurring antinociceptive compounds rutin, geraniin and quercetine extracted from Phyllanthus, as well as the diterpene jatrophone, extracted from Jatropha elliptica on the binding of [3H]glutamate and [3H]GMP-PNP [a GTP analogue which binds to extracellular site(s), modulating the glutamatergic transmission] in rat brain membrane. Jatrophone inhibited [3H]glutamate binding and geraniin inhibited [3H]GMP-PNP binding. Quercetine inhibited the binding of both ligands. These results may indicate a neurochemical parameter possibly related to the antinoceptive activity of these natural compounds.

引用

页码：211 / 215

页数：4

共 50 条

[41] The effect of adrenotropic agents on [3H]quinuclidinyl benzylate binding to M-cholinoceptors of rat cerebral cortex
Nesterova, LA
Smurova, EA
Manukhin, BN
BIOLOGICHESKIE MEMBRANY, 2001, 18 (02): : 103 - 110
[42] Effect of inhibitory avoidance training on [3H]-glutamate binding in the hippocampus and parietal cortex of rats
Schröder, N
de-Paris, F
Roesler, R
Medina, JH
Souza, DO
Izquierdo, I
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2000, 33 (02) : 229 - 232
[43] Enhanced displacement of [3H]imipramine, but not [3H]paroxetine binding by plasma from depressed patients
Lawrence, KM
Lowther, S
Falkowski, J
Jacobson, RR
Horton, RW
JOURNAL OF AFFECTIVE DISORDERS, 1997, 46 (02) : 127 - 134
[44] Changes of [3H]muscimol, [3H]flunitrazepam and [3H]MK-801 binding in rat brain by prolonged ventricular infusion of 7-nitroindazole
Kim, EY
Shin, KM
Jang, S
Oh, SW
NEUROCHEMICAL RESEARCH, 2004, 29 (12) : 2221 - 2229
[45] Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex
Zhang, YH
Zhao, XY
Chen, XQ
Wang, Y
Yang, HH
Hu, GY
NEUROSCIENCE LETTERS, 2002, 319 (02) : 107 - 110
[46] Effect of dithiol chelating agents on [3H]MK-801 and [3H]glutamate binding to synaptic plasma membranes
Nogueira, CW
Rocha, JBT
Souza, DO
NEUROCHEMICAL RESEARCH, 2001, 26 (12) : 1305 - 1310
[47] Changes of [3H]Muscimol, [3H]Flunitrazepam and [3H]MK-801 Binding in Rat Brain by Prolonged Ventricular Infusion of 7-Nitroindazole
Eun Young Kim
Kyu Man Shin
Soyong Jang
Seikwan Oh
Neurochemical Research, 2004, 29 : 2221 - 2229
[48] Effects of gabapentin and pregabalin on K+-evoked [3H]-GABA and [3H]-glutamate release from rat and human neocortical synaptosomes
Brawek, B.
Weyerbrock, A.
Feuerstein, T. J.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2008, 377 : 48 - 48
[49] Purification of an inhibitor of [3H]glutamate binding in the supernatant of washed synaptosome solution from rat brain
Maruyama, M
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R140 - R140
[50] Inhibitory effect of nociceptin on [3H]-5HT release from the rat cerebral cortex
Siniscalchi, A
Sbrenna, S
Rodi, D
Beani, L
Bianchi, C
BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 : U138 - U138

← 1 2 3 4 5 →