Compounds Extracted from Phyllantus and Jatropha elliptica Inhibit the Binding of [3H]Glutamate and [3H]GMP-PNP in Rat Cerebral Cortex Membrane

被引：0
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作者：
Lúcia H. Martini
Carla R. Souza
Patricia B. Marques
João B. Calixto
Rosendo A. Yunes
Diogo O. Souza
机构：
[1] Universidade Federal do Rio Grande do Sul,Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde
[2] Departamentos de Farmacologia,Química
[3] Universidade Federal de Santa Catarina,Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde
[4] Florianópolis,undefined
[5] Universidade Federal do Rio Grande do Sul,undefined
来源：
Neurochemical Research | 2000年 / 25卷
关键词：
Glutamate; guanine nucleotides; antinoception; naturally-occurring compounds;
D O I：
暂无
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学科分类号：
摘要：
Glutamate is to be considered a nociceptive neurotransmitter and glutamatergic antagonists present antinoceptive activity. In this study we investigated the effects of the naturally occurring antinociceptive compounds rutin, geraniin and quercetine extracted from Phyllanthus, as well as the diterpene jatrophone, extracted from Jatropha elliptica on the binding of [3H]glutamate and [3H]GMP-PNP [a GTP analogue which binds to extracellular site(s), modulating the glutamatergic transmission] in rat brain membrane. Jatrophone inhibited [3H]glutamate binding and geraniin inhibited [3H]GMP-PNP binding. Quercetine inhibited the binding of both ligands. These results may indicate a neurochemical parameter possibly related to the antinoceptive activity of these natural compounds.
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页码：211 / 215
页数：4
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