Time Factor in External Radiotherapy: Radiobiological Mechanisms and Clinical Applications

被引：0
|
作者：
Abdelhak Maghous
El-Amin Marnouche
Mouhcine Hommadi
Maroua Belemlih
Noha Zaghba
Ayoub Ennadif
Amine Bazine
Issam Lalya
Khalid Andaloussi Saghir
Mohamed Elmarjany
Khalid Hadadi
Hassan Sifat
机构：
[1] Hassan II University (Univh2c) of Casablanca,Faculty of Medicine and Pharmacy Casablanca (FMPC), Mohammed V Military Teaching Hospital
[2] Mohammed V University in Rabat,Department of Radiotherapy, Mohammed V Military Teaching Hospital
来源：
Indian Journal of Gynecologic Oncology | 2024年 / 22卷
关键词：
External radiotherapy; Fractionation; Spreading; Radiobiology; Repair of sublethal damage; Redistribution in cell cycle; Reoxygenation; Repopulation; Hyperfractionation; Accelerated treatment; Hypofractionated treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review article explores the critical role of time in external radiotherapy, focusing on the concepts of fractionation and spreading. It traces the evolution of radiobiology, highlighting key milestones that have shaped current treatment strategies. The article delves into the four fundamental principles of radiobiology—Repair, Redistribution, Reoxygenation, and Repopulation—and their implications for fractionated radiation therapy. It further discusses the clinical applications of these principles, including hyperfractionated, accelerated, and hypofractionated treatments. This review provides a comprehensive understanding of how the time factor influences the effectiveness of radiotherapy and its impact on healthy and tumor tissues.
引用
收藏
相关论文
共 50 条
  • [11] Particle radiotherapy and molecular therapies: mechanisms and strategies towards clinical applications
    Helm, Alexander
    Fournier, Claudia
    Durante, Marco
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2022, 24
  • [12] Late radiation-induced heart disease after radiotherapy. Clinical importance, radiobiological mechanisms and strategies of prevention
    Andratschke, Nicolaus
    Maurer, Jean
    Molls, Michael
    Trott, Klaus-Ruediger
    RADIOTHERAPY AND ONCOLOGY, 2011, 100 (02) : 160 - 166
  • [13] Translational Research in FLASH Radiotherapy-From Radiobiological Mechanisms to In Vivo Results
    Marcu, Loredana G.
    Bezak, Eva
    Peukert, Dylan D.
    Wilson, Puthenparampil
    BIOMEDICINES, 2021, 9 (02) : 1 - 16
  • [14] Alpha-Emitter Radiopharmaceuticals and External Beam Radiotherapy: A Radiobiological Model for the Combined Treatment
    Sarnelli, Anna
    Belli, Maria Luisa
    Azzali, Irene
    Loi, Emiliano
    Severi, Stefano
    Strigari, Lidia
    CANCERS, 2022, 14 (04)
  • [15] Radiobiological considerations in combining doses from external beam radiotherapy and brachytherapy for cervical cancer
    Tornero-Lopez, Ana M.
    Guirado, Damian
    REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2018, 23 (06) : 562 - 573
  • [16] STUDIES CONCERNING THE EVALUATION OF THE TIME FACTOR IN RADIOBIOLOGICAL EFFECTS
    GOLDFEDER, A
    CLARKE, GE
    RADIATION RESEARCH, 1957, 7 (03) : 318 - 318
  • [17] Particle beam radiotherapy for head and neck tumors: Radiobiological basis and clinical experience
    Jereczek-Fossa, Barbara Alicja
    Krengli, Marco
    Orecchia, Roberto
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2006, 28 (08): : 750 - 760
  • [18] RADIOBIOLOGICAL INTERCOMPARISON OF NEUTRON BEAMS USED FOR CLINICAL-APPLICATIONS
    BEAUDUIN, M
    GUELETTE, J
    VYNCKIER, S
    STRIJCKMANS, K
    AISSI, A
    HANNAN, M
    WAMBERSIE, A
    BRITISH JOURNAL OF RADIOLOGY, 1987, 60 (711): : 316 - 316
  • [19] SOME RADIOBIOLOGICAL BASES OF TIME-DISTRIBUTION AND DOSE-DISTRIBUTION IN RADIOTHERAPY
    STREFFER, C
    STRAHLENTHERAPIE UND ONKOLOGIE, 1988, 164 (11): : 648 - 652
  • [20] RADIOBIOLOGICAL EVALUATION OF THE CLINICAL IMPACT FOR LUNG RADIOTHERAPY OF ALTERNATIVE PHOTON DOSE ALGORITHMS
    Chandrasekarar, M.
    Panettieri, V.
    Popescu, I. A.
    Uzan, J.
    Baker, C.
    Nahum, E.
    RADIOTHERAPY AND ONCOLOGY, 2010, 96 : S609 - S609
12345