The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans

被引:0
|
作者
I. Niopas
S. Toon
L. Aarons
M. Rowland
机构
[1] Department of Pharmacy,
[2] Aristotle University of Thessaloniki,undefined
[3] GR-54006 Thessaloniki,undefined
[4] Greece,undefined
[5] Medeval Ltd.,undefined
[6] Skelton House,undefined
[7] Manchester Science Park,undefined
[8] Manchester M15 4SH,undefined
[9] UK,undefined
[10] School of Pharmacy and Pharmaceutical Sciences,undefined
[11] University of Manchester,undefined
[12] Manchester M13 9PL,undefined
[13] UK e-mail: Isung@fs1.pa.man.ac.uk Tel.: +44-161-2752348; Fax: +44-161-273-8196,undefined
来源
European Journal of Clinical Pharmacology | 1999年 / 55卷
关键词
Key words Warfarin; Cimetidine; Drug; drug interaction;
D O I
暂无
中图分类号
学科分类号
摘要
Objective: The interaction of multiple oral doses of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin was investigated in six healthy male volunteers.
引用
收藏
页码:399 / 404
页数:5
相关论文
共 50 条
  • [31] Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects
    Smulders, R. A.
    Kuipers, M. E.
    Krauwinkel, W. J. J.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 62 (02) : 210 - 217
  • [32] STEADY-STATE PHARMACOKINETICS AND PHARMACODYNAMICS OF CILAZAPRIL IN THE PRESENCE AND ABSENCE OF CYCLOPENTHIAZIDE
    KRUM, H
    JACKSON, B
    CONWAY, EL
    HOWES, LG
    JOHNSTON, CI
    LOUIS, WJ
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 (03) : 451 - 457
  • [33] Fosinopril/hydrochlorothiazide: single dose and steady-state pharmacokinetics and pharmacodynamics
    O'Grady, P
    Yee, KF
    Lins, R
    Mangold, B
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 48 (03) : 375 - 381
  • [34] PROPRANOLOL PHARMACOKINETICS AND PHARMACODYNAMICS AFTER SINGLE DOSES AND AT STEADY-STATE
    LALONDE, RL
    PIEPER, JA
    STRAKA, RJ
    BOTTORFF, MB
    MIRVIS, DM
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 33 (03) : 315 - 318
  • [35] No effect of steady-state dosing of zonisamide on pharmacokinetics and pharmacodynamics of an oral contraceptive in healthy females
    Griffith, SG
    Shah, J
    Kovelesky, RA
    Dai, Y
    EPILEPSIA, 2004, 45 : 156 - 156
  • [36] COMPARATIVE EFFECTS OF RANITIDINE AND CIMETIDINE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF WARFARIN IN MAN
    TOON, S
    HOPKINS, KJ
    GARSTANG, FM
    ROWLAND, M
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 32 (02) : 165 - 172
  • [37] The effect of multiple doses of cimetidine on the steady-state pharmacokinetics of quetiapine in men with selected psychotic disorders
    Strakowski, SM
    Keck, PE
    Wong, YWJ
    Thyrum, PT
    Yeh, C
    JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2002, 22 (02) : 201 - 205
  • [38] EFFECT OF CIMETIDINE ON STEADY-STATE SERUM DIGOXIN CONCENTRATIONS
    FRALEY, DS
    BRITTON, HL
    SCHWINGHAMMER, TL
    KALLA, R
    CLINICAL PHARMACY, 1983, 2 (02): : 163 - 165
  • [39] EFFECT OF CIMETIDINE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF QUINIDINE
    HARDY, BG
    ZADOR, IT
    GOLDEN, L
    LALKA, D
    SCHENTAG, JJ
    AMERICAN JOURNAL OF CARDIOLOGY, 1983, 52 (01): : 172 - 175
  • [40] EFFECT OF ANTACIDS ON PREDICTED STEADY-STATE CIMETIDINE CONCENTRATIONS
    RUSSELL, WL
    LOPEZ, LM
    NORMANN, SA
    DOERING, PL
    GUILD, RT
    DIGESTIVE DISEASES AND SCIENCES, 1984, 29 (05) : 385 - 389