Including known covariates can reduce power to detect genetic effects in case-control studies

被引：0
|
作者：
Matti Pirinen
Peter Donnelly
Chris C A Spencer
机构：
[1] Wellcome Trust Centre for Human Genetics,Department of Statistics
[2] University of Oxford,undefined
[3] University of Oxford,undefined
来源：
Nature Genetics | 2012年 / 44卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peter Donnelly and colleagues report an analysis considering the inclusion of non-confounding covariates within genome-wide association studies and provide software that can be used to assess the impact on power within a particular study. They find that, when the disease prevalence is low, including known covariates, such as sex or established genetic associations, can reduce the power to detect new associations.
引用
下载
收藏
页码：848 / 851
页数：3
相关论文
共 50 条
  • [11] The Power of Independent Types of Genetic Information to Detect Association in a Case-Control Study Design
    Won, Sungho
    Elston, Robert C.
    GENETIC EPIDEMIOLOGY, 2008, 32 (08) : 731 - 756
  • [12] Maternal genotype effects can alias case genotype effects in case-control studies
    Buyske, Steven
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (07) : 783 - 785
  • [13] Sample size requirements to detect the effect of a group of genetic variants in case-control studies
    Moonesinghe R.
    Yang Q.
    Khoury M.J.
    Emerging Themes in Epidemiology, 5 (1):
  • [14] CASE DEFINITION AND POWER IN CASE-CONTROL STUDIES
    ROSENBAUM, PR
    STATISTICS IN MEDICINE, 1984, 3 (01) : 27 - 34
  • [15] Score tests in the presence of errors in covariates in matched case-control studies
    Sinha, Samiran
    Yoo, Seungyoon
    JOURNAL OF MULTIVARIATE ANALYSIS, 2013, 115 : 157 - 171
  • [16] Incorporation of covariates into multipoint linkage disequilibrium mapping in case-control studies
    Chiu, Yen-Feng
    Liang, Kung-Yee
    Chuang, Lee-Ming
    Beaty, Terri H.
    GENETIC EPIDEMIOLOGY, 2008, 32 (02) : 143 - 151
  • [17] Semiparametric approaches for matched case-control studies with error-in-covariates
    Johnson, Nels G.
    Kim, Inyoung
    COMPUTATIONAL STATISTICS, 2019, 34 (04) : 1675 - 1692
  • [18] A new semiparametric procedure for matched case-control studies with missing covariates
    Sinha, Samiran
    Wang, Suojin
    JOURNAL OF NONPARAMETRIC STATISTICS, 2009, 21 (07) : 889 - 905
  • [19] Power and replication in case-control studies
    Lalouel, LM
    Rohrwasser, A
    AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (02) : 201 - 205
  • [20] Bias in case-control studies: can it be avoided?
    Souza, Fernanda de Oliveira
    Miranda, Samilly Silva
    Pinho Valente, Alessandra Lais
    Smolen, Jenny Rose
    de Araujo, Tania Maria
    REVISTA DE EPIDEMIOLOGIA E CONTROLE DE INFECCAO, 2016, 6 (02): : 92 - 96
12345