Synthesis of (−)-neplanocin A analogues as potential antiviral agents

被引：0
|
作者：
Dae Hong Shin
Hyuk Woo Lee
Sung Soo Park
Joong Hyup Kim
Lak Shin Jeong
Moon Woo Chun
机构：
[1] Seoul National University,College of Pharmacy
[2] Korea Institute of Science and Technology,College of Pharmacy
[3] Ewha Womans University,undefined
来源：
Archives of Pharmacal Research | 2000年 / 23卷
关键词：
Neplanocin A; Nucleosides; Antiviral activity; Cytotoxicity; -adenosylhomocysteine hydrolase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Based on (-)-neplanocin A with the 5’-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo-and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
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页码：302 / 309
页数：7
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