Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

被引：0

作者：

Andrea Giovannucci

Aleksandra Badura

Ben Deverett

Farzaneh Najafi

Talmo D Pereira

Zhenyu Gao

Ilker Ozden

Alexander D Kloth

Eftychios Pnevmatikakis

Liam Paninski

Chris I De Zeeuw

Javier F Medina

Samuel S-H Wang

机构：

[1] Princeton University,Princeton Neuroscience Institute and Department of Molecular Biology

[2] Center for Computational Biology,Department of Biology

[3] Flatiron Institute,Department of Neuroscience

[4] Simons Foundation,Departments of Statistics and Neuroscience

[5] Netherlands Institute for Neuroscience,Department of Neuroscience

[6] Robert Wood Johnson Medical School,undefined

[7] University of Pennsylvania,undefined

[8] Erasmus MC,undefined

[9] School of Engineering,undefined

[10] Brown University,undefined

[11] Columbia University,undefined

[12] Baylor College of Medicine,undefined

[13] Present addresses: Cold Spring Harbor Laboratory,undefined

[14] Cold Spring Harbor,undefined

[15] New York,undefined

[16] USA (F.N.) and University of North Carolina,undefined

[17] Chapel Hill,undefined

[18] North Carolina,undefined

[19] USA (A.D.K.).,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Granule cells constitute half of the cells in the brain, yet their activity during behavior is largely uncharacterized. The authors report that granule cells encode multisensory representations that evolve with learning into a predictive motor signal. This activity may help the cerebellum implement a forward model for action.

引用

页码：727 / 734

页数：7

共 50 条

[21] Temporal dynamics of cerebellar and motor cortex physiological processes during motor skill learning
Spampinato, D.
Celnik, P.
SCIENTIFIC REPORTS, 2017, 7
[22] The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning
Li Zhang
Sookja Kim Chung
Billy Kwok Chong Chow
Neuropsychopharmacology, 2014, 39 : 1460 - 1468
[23] The effect of cyclic phosphatidic acid on the proliferation and differentiation of mouse cerebellar granule precursor cells during cerebellar development
Konakazawa, Misa
Gotoh, Mari
Murakami-Murofushi, Kimiko
Hamano, Ayana
Miyamoto, Yasunori
BRAIN RESEARCH, 2015, 1614 : 28 - 37
[24] The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning
Zhang, Li
Chung, Sookja Kim
Chow, Billy Kwok Chong
NEUROPSYCHOPHARMACOLOGY, 2014, 39 (06) : 1460 - 1468
[25] Dynamic Associations in the Cerebellar-Motoneuron Network during Motor Learning
Sanchez-Campusano, Raudel
Gruart, Agnes
Delgado-Garcia, Jose M.
JOURNAL OF NEUROSCIENCE, 2009, 29 (34): : 10750 - 10763
[26] Central regulation of cerebellar climbing fibre input during motor learning
Apps, R
Lee, S
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 541 (01): : 301 - 317
[27] Decreased Tonic Inhibition in Cerebellar Granule Cells Causes Motor Dysfunction in a Mouse Model of Angelman Syndrome
Egawa, Kiyoshi
Kitagawa, Kyoko
Inoue, Koichi
Takayama, Masakazu
Takayama, Chitoshi
Saitoh, Shinji
Kishino, Tatsuya
Kitagawa, Masatoshi
Fukuda, Atsuo
SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (163)
[28] Morphological and Biochemical Changes During Programmed Cell Death of Rat Cerebellar Granule Cells
Jason Y. Chang
Jian-Zhong Wang
Neurochemical Research, 1997, 22 : 43 - 48
[29] Morphological and biochemical changes during programmed cell death of rat cerebellar granule cells
Chang, JY
Wang, JZ
NEUROCHEMICAL RESEARCH, 1997, 22 (01) : 43 - 48
[30] THE EFFECTS OF AUTONOMY DURING PRACTICE ON FEEDBACK PROCESSING AND MOTOR LEARNING
Miller, Matthew W.
Grand, Kirk
PSYCHOPHYSIOLOGY, 2016, 53 : S10 - S10

← 1 2 3 4 5 →