Microwave-assisted Solid Phase Peptide Synthesis on High Loaded Resins

被引：0
|
作者：
Stéphanie Coantic
Gilles Subra
Jean Martinez
机构：
[1] Institut de Chimie Séparative de Marcoule,Faculté de Pharmacie de Montpellier
[2] UMR CNRS 5257,undefined
[3] CEA Valrhô/DRCP/SCPS/LCAM,undefined
[4] Institut des Biomolécules Max Mousseron UMR CNRS 5247,undefined
[5] Universités Montpellier I et II,undefined
来源：
International Journal of Peptide Research and Therapeutics | 2008年 / 14卷
关键词：
SPPS; Microwave-assisted peptide synthesis; Resin beads; Mechanical stirring;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Kinetic of diffusion of reactants from the solution into the resin beads is a key factor of the efficiency of reaction in solid phase synthesis. We demonstrated in this paper that stirring is required to obtain homogeneous solution during the short coupling steps in microwave-assisted SPPS. Different types of resin, loading rate and coupling reactants were investigated to highlight this observation.
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页码：143 / 147
页数：4
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