Peculiarities of bone marrow hemopoiesis in early aging OXYS rats

被引：0
|
作者：
I. A. Orlovskaya
L. B. Toporkova
N. A. Feofanova
N. G. Kolosova
机构：
[1] Siberian Division of Russian Academy of Medical Sciences,Institute of Clinical Immunology
[2] Siberian Division of Russian Academy of Sciences,Institute of Cytology and Genetics
来源：
Bulletin of Experimental Biology and Medicine | 2007年 / 144卷
关键词：
hemopoietic precursors; hemopoietic stem cell; early aging; OXYS rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Colony-forming activity of bone marrow cells in 3-and 12-month-old Wistar rats does not differ by the number of early and erythroid precursors and by the formation of granulocyte-macrophage colonies. In senescence-accelerated OXYS rats, the number of early and erythroid precursors significantly increases by the age of 12 months and surpasses the corresponding values in Wistar rats. The number of granulocyte-macrophage colonies in OXYS rats does not change with age, but the numbers of these colonies formed at the age of 3 and 12 months in these animals are higher than in Wistar rats. As a result, the total number of hemopoietic colonies in 12-month-old OXYS rats 2-fold surpassed that in 12-month-old Wistar rats. Activation of granulopoiesis and increased numbers of early and erythroid precursors indicate deep changes in the functional status of the hemopoietic stem cell in 1-year-old OXYS rats in the direction characteristic of aging animals.
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页码：86 / 88
页数：2
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