Role of K1 capsule antigen in cirrhotic patients with Escherichia coli spontaneous bacterial peritonitis in southern Taiwan

被引:0
|
作者
M. C. Wang
W. H. Lin
C. C. Tseng
A. B. Wu
C. H. Teng
J. J. Yan
J. J. Wu
机构
[1] College of Medicine,Department of Internal Medicine, National Cheng Kung University Hospital
[2] National Cheng Kung University,Institute of Clinical Pharmacy and Pharmaceutical Sciences
[3] College of Medicine,Institute of Clinical Medicine
[4] National Cheng Kung University,Institute of Molecular Medicine
[5] College of Medicine,Department of Pathology, National Cheng Kung University Hospital
[6] National Cheng Kung University,Department of Medical Laboratory Science and Biotechnology, Infectious Disease and Signaling Research Center
[7] College of Medicine,undefined
[8] National Cheng Kung University,undefined
[9] College of Medicine,undefined
[10] National Cheng Kung University,undefined
[11] College of Medicine,undefined
[12] National Cheng Kung University,undefined
来源
European Journal of Clinical Microbiology & Infectious Diseases | 2013年 / 32卷
关键词
Cirrhotic Patient; Cefpodoxime; Spontaneous Bacterial Peritonitis; Intestinal Perforation; Cefpirome;
D O I
暂无
中图分类号
学科分类号
摘要
Spontaneous bacterial peritonitis (SBP) is one of the most serious complications in patients with cirrhosis. This study aimed to investigate the prevalence of SBP caused by Escherichia coli isolates with or without the K1 capsule antigen in cirrhotic patients and the outcome. From January 2004 to January 2012, a total of 54 and 41 E. coli strains derived from patients with SBP and intestinal perforation (IP), respectively, were included for comparison in this study. Bacterial characteristics including phylogenetic groups, K1 capsule antigen, and 14 virulence factor genetic determinants, as well as data regarding patient characteristics, clinical manifestations, and in-hospital deaths, were collected and analyzed. The prevalence of the K1 capsule antigen gene neuA was more common in SBP isolates compared to IP isolates (28 % vs. 10 %, p = 0.0385). Phylogenetic groups B2 and group D were dominant in E. coli isolates with and without the K1 capsule antigen, respectively. The prevalence of virulence factors genes papG II, ompT, and usp was higher in E. coli K1 strains. There were 26 deaths (48 %) during hospitalization. Presence of the K1 capsule antigen in E. coli isolates was significantly associated with in-hospital death in cirrhotic patients with SBP (42 % vs. 14 %, p = 0.0331). This study demonstrates a higher prevalence of the K1 capsule antigen in E. coli SBP compared to E. coli peritonitis caused by IP. There were significant associations between the K1 capsule antigen and in-hospital mortality and bacterial virulence in cirrhotic patients with E. coli SBP.
引用
收藏
页码:407 / 412
页数:5
相关论文
共 50 条
  • [21] RELAPSING ESCHERICHIA-COLI K1 ANTIGEN MENINGITIS IN A NEWBORN
    HELMS, PJ
    ARCHIVES OF DISEASE IN CHILDHOOD, 1977, 52 (02) : 152 - 154
  • [22] PROPHYLAXIS OF THE 1ST SPONTANEOUS BACTERIAL PERITONITIS IN CIRRHOTIC-PATIENTS
    NOVELLA, MT
    SORIANO, G
    GANA, J
    ANDREU, M
    ORTIZ, J
    COLL, S
    SABAT, M
    VILA, MC
    GUARNER, C
    SOLA, R
    VILARDELL, F
    HEPATOLOGY, 1994, 20 (04) : A115 - A115
  • [23] Role of CD14 in responses to clinical isolates of Escherichia coli:: Effects of K1 capsule expression
    Metkar, Shalaka
    Awasthi, Shanjana
    Denamur, Erick
    Kim, Kwang Sik
    Gangloff, Sophie C.
    Teichberg, Saul
    Haziot, Alain
    Silver, Jack
    Goyert, Sanna M.
    INFECTION AND IMMUNITY, 2007, 75 (11) : 5415 - 5424
  • [24] A bioorthogonal chemistry approach to detect the K1 polysialic acid capsule in Escherichia coli
    Rigolot, Vincent
    Rossez, Yannick
    Biot, Christophe
    Lion, Cedric
    RSC CHEMICAL BIOLOGY, 2023, 4 (02): : 173 - 183
  • [25] Escherichia coli K1's capsule is a barrier to bacteriophage T7
    Scholl, D
    Adhya, S
    Merril, C
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2005, 71 (08) : 4872 - 4874
  • [26] ISOLATION OF BACTERIOPHAGES SPECIFIC FOR K1 POLYSACCHARIDE ANTIGEN OF ESCHERICHIA-COLI
    GROSS, RJ
    CHEASTY, T
    ROWE, B
    JOURNAL OF CLINICAL MICROBIOLOGY, 1977, 6 (06) : 548 - 550
  • [27] CLINICAL SIGNIFICANCE OF ESCHERICHIA-COLI K1 ANTIGEN IN NEONATAL MENINGITIS
    MCCRACKEN, GH
    SARFF, LD
    GLODE, MP
    ROBBINS, JB
    SCHIFFER, M
    ORSKOV, I
    ORSKOV, F
    GOTSCHLICH, E
    PEDIATRIC RESEARCH, 1974, 8 (04) : 427 - 427
  • [28] Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites
    de Vos, Marie
    De Vroey, Benedicte
    Garcia, Beatrice Garcia
    Roy, Clothilde
    Kidd, Francois
    Henrion, Jean
    Deltenre, Pierre
    LIVER INTERNATIONAL, 2013, 33 (09) : 1316 - 1323
  • [29] PROTECTION AGAINST ESCHERICHIA-COLI K1 INFECTION IN NEWBORN RATS BY ANTIBODY TO K1 CAPSULAR POLYSACCHARIDE ANTIGEN
    BORTOLUSSI, R
    FERRIERI, P
    INFECTION AND IMMUNITY, 1980, 28 (01) : 111 - 117
  • [30] Mobile contingency locus controlling Escherichia coli K1 polysialic acid capsule acetylation
    Vimr, ER
    Steenbergen, SM
    MOLECULAR MICROBIOLOGY, 2006, 60 (04) : 828 - 837