A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

被引：0
|
作者：
Zhengwei Zhang
Jingjie Ge
Kai Jing
Yefeng Chen
Yihui Guan
Hexin Xie
Jianhua Zhu
机构：
[1] Fudan University,Department of Radiopharmacy, School of Pharmacy
[2] Fudan University,PET Center, Huashan Hospital
[3] East China University of Science and Technology,School of Pharmacy
来源：
Medicinal Chemistry Research | 2022年 / 31卷
关键词：
6-[; F]fluoro-L-DOPA; Radiosynthesis; Positron emission tomography; Congenital hyperinsulinism; Imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
6-[18F]fluoro-L-DOPA is a radiotracer widely used in the diagnosis of a range of diseases, including neuro-oncology, endocrinology, and Parkinson’s disease. To meet the rapidly growing clinical need for this radioactive compound, this study reports an optimized radiosynthesis for this molecule, which proved to be highly reliable and compatible with different types of automated radiosynthesizers. Moreover, with 6-[18F]fluoro-L-DOPA, the PET/CT imaging of a total of 23 patients has been conducted, further demonstrating this radiotracer as a clinically valuable reagent to diagnose congenital hyperinsulinism (CHI) of infants in a non-invasive manner and, more importantly, localize the exact lesion on pancreas.
引用
收藏
页码：1126 / 1134
页数：8
相关论文
共 50 条
  • [21] Enzymatic synthesis of no-carrier-added 6-[18F]fluoro-L-dopa with β-tyrosinase
    Kaneko, S
    Ishiwata, K
    Hatano, K
    Omura, H
    Ito, K
    Senda, M
    APPLIED RADIATION AND ISOTOPES, 1999, 50 (06) : 1025 - 1032
  • [22] Enantioelective synthesis of no-carrier-added (NCA) 6-[18F]fluoro-L-DOPA
    Zhang, L
    Tang, GH
    Yin, DZ
    Tang, XL
    Wang, YX
    APPLIED RADIATION AND ISOTOPES, 2002, 57 (02) : 145 - 151
  • [23] Evaluation of dopaminergic presynaptic integrity:: 6-[18F]fluoro-L-dopa versus 6-[18F]fluoro-L-m-tyrosine
    Doudet, DJ
    Chan, GLY
    Jivan, S
    DeJesus, OT
    McGeer, EG
    English, C
    Ruth, TJ
    Holden, JE
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (03): : 278 - 287
  • [24] Automated copper-mediated synthesis of 6-[18F]fluoro-L-DOPA using the Ora Neptis® Synthesizer
    Hienzsch, Antje
    Wolfrum, Anja
    Clemens, Anna
    Preshlock, Sean
    Verhoog, Stefan
    Gouverneur, Veronique
    Mollitor, Jan
    Hoepping, Alexander
    Mueller, Marco
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2017, 60 : S477 - S477
  • [25] Automated synthesis of 6-[18F]fluoro-L-DOPA using modified polystyrene supports with bound 6-mercuric DOPA precursors
    Szajek, LP
    Channing, MA
    Eckelman, WC
    APPLIED RADIATION AND ISOTOPES, 1998, 49 (07) : 795 - 804
  • [26] Automated synthesis of 6-[18F]fluoro-L-DOPA using modified polystyrene supports with bound 6-mercuric DOPA precursors
    PET Department, Warren Grant Magnuson Clin. Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States
    Appl. Radiat. Isot., 7 (795-804):
  • [27] Pancreatic dopamine metabolism in congenital hyperinsulinism.: A [18F]fluoro-L-dopa pet study
    Ribeiro, M. J.
    Bellanne-Chantelot, C.
    Valayannopoulos, V.
    Delzescaux, T.
    Jaubert, F.
    Aigrain, Y.
    Nihoul-Fekete, C.
    Brunelle, F.
    de Lonlay, P.
    JOURNAL OF INHERITED METABOLIC DISEASE, 2008, 31 : 47 - 47
  • [28] [18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA
    Stenhagen, Ida S. R.
    Kirjavainen, Anna K.
    Forsback, Sarita J.
    Jorgensen, Charlotte G.
    Robins, Edward G.
    Luthra, Sajinder K.
    Solin, Olof
    Gouverneur, Veronique
    CHEMICAL COMMUNICATIONS, 2013, 49 (14) : 1386 - 1388
  • [29] One pot synthesis of [18F] labelled benzyl chloride for asymmetric nucleophilic synthesis of 6-[18F] fluoro-L-DOPA
    Orlovskaja, V.
    Fedorova, O.
    Studentsov, E.
    Golovina, A.
    Krasikova, R.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 : S849 - S849
  • [30] Functional imaging of the pancreas:: The role of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy
    Ribeiro, Maria-Joao
    Boddaert, Nathalie
    Delzescaux, Thierry
    Valayannopoulos, Vassili
    Bellanne-Chantelot, Christine
    Jaubert, Francis
    Verkarre, Virginie
    Nihoul-Fekete, Claire
    Brunelle, Francis
    De Lonlay, Pascale
    DEVELOPMENT OF THE PANCREAS AND NEONATAL DIABETES, 2007, 12 : 55 - 66
12345