Production of proteinase–plasminogen activators by micromycete Tolypocladium inflatum k1

被引：0

作者：

T. S. Sharkova

E. O. Matveeva

V. G. Kreier

A. A. Osmolovskiy

A. V. Kurakov

N. A. Baranova

N. S. Egorov

机构：

[1] M.V. Lomonosov Moscow State University,Department of Biology

[2] M.V. Lomonosov Moscow State University,Department of Biotechnology

[3] Lomonosov Moscow State University,International Center of Biotechnology

来源：

Applied Biochemistry and Microbiology | 2016年 / 52卷

关键词：

micromycete extracellular proteinases; fibrinolytic enzymes; proteinase–plasminogen activators;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The cultivation conditions (cultivation duration, nitrogen sources, and initial pH of the medium) of the strain Tolypocladium inflatum k1, a producer of extracellular proteases, has been optimized to achieve maximal plasminogen activator activity. It has been shown that Tolypocladium inflatum k1 forms at least two proteinases with activator activity towards plasminogen. One of them is thiol-dependent, EDTA-sensitive serine proteinase, which activates plasminogen and does not hydrolyze fibrin, indicating its higher specificity and prospects for the development of new thrombolytic agents.

引用

页码：31 / 35

页数：4

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