The influence of the azimuthal crystallographic orientation on the strength of single-crystal cooled turbine rotor blades is studied. The effect of the cooling system features on the rational choice of the azimuthal crystallographic orientation of modern single-crystal cooled turbine rotor blades is shown. The improvement in the structure and cooling systems of single-crystal cooled turbine rotor blades makes it possible to reduce the influence of the azimuthal crystallographic orientation on their stress state.