Synthesis and Cardiotropic Activity of N,N′-Diarylpropane-1,3-Diamines

We report here the synthesis of novel compounds of the bis-(2,3,4-trimethoxybenzyl)propanediamines group and studies of their anti-ischemic and antiarrhythmic activity. Introduction of a hydroxyl group into the central part of the propane linker was found to produce virtually no change in the spectrum of cardiotropic properties of the unsubstituted compound ALM-851, while introduction of two methyl groups led to the complete disappearance of both antiarrhythmic and antiischemic activities. Compound ALM-850 (1,3-bis((2,3,4-trimethoxy-benzyl)amino)propan-2-oldihydrochloride) at a dose of 3 mg/kg significantly blocked the development of rhythm disturbances and death in animals in the aconitine and calcium chloride arrhythmia models, and also decreased ST segment depression in the isoproterenol ischemia model.