Molecular phenotyping of T-cell-mediated rejection

被引：0

作者：

Anita S. Chong

David L. Perkins

机构：

[1] University of Chicago,Department of Surgery

[2] University of Illinois,Department of Surgery

来源：

Nature Reviews Nephrology | 2014年 / 10卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.

引用

页码：678 / 680

页数：2

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