Molecular phenotyping of T-cell-mediated rejection

被引:0
|
作者
Anita S. Chong
David L. Perkins
机构
[1] University of Chicago,Department of Surgery
[2] University of Illinois,Department of Surgery
来源
Nature Reviews Nephrology | 2014年 / 10卷
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摘要
A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.
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页码:678 / 680
页数:2
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