ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7

被引：0

作者：

Robert J. Fischer

Neeltje van Doremalen

Danielle R. Adney

Claude Kwe Yinda

Julia R. Port

Myndi G. Holbrook

Jonathan E. Schulz

Brandi N. Williamson

Tina Thomas

Kent Barbian

Sarah L. Anzick

Stacy Ricklefs

Brian J. Smith

Dan Long

Craig Martens

Greg Saturday

Emmie de Wit

Sarah C. Gilbert

Teresa Lambe

Vincent J. Munster

机构：

[1] National Institute of Allergy and Infectious Diseases,Laboratory of Virology

[2] National Institutes of Health,Research Technologies Branch, Rocky Mountain Laboratories

[3] National Institutes of Health,Rocky Mountain Veterinary Branch

[4] National Institute of Allergy and Infectious Diseases,The Jenner Institute, Nuffield Department of Medicine

[5] National Institutes of Health,undefined

[6] University of Oxford,undefined

来源：

Nature Communications | / 12卷

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摘要：

We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs.

引用

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Yinda, Claude Kwe
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Holbrook, Myndi G.
Schulz, Jonathan E.
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Barbian, Kent
Anzick, Sarah L.
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Smith, Brian J.
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Martens, Craig
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de Wit, Emmie
Gilbert, Sarah C.
Lambe, Teresa
Munster, Vincent J.
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