Leading-edge research: PtdIns(3,4,5)P3 and directed migration

被引：0
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作者：
Jonathan Franca-Koh
Yoichiro Kamimura
Peter N. Devreotes
机构：
[1] Johns Hopkins University School of Medicine,Department of Cell Biology
[2] 725 North Wolfe Street,undefined
[3] 114 WBSB,undefined
来源：
Nature Cell Biology | 2007年 / 9卷
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摘要：
New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.
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页码：15 / 17
页数：2
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