Leading-edge research:: Ptdlns(3,4,5) P3 and directed migration

被引：53
|
作者：
Franca-Koh, Jonathan [1 ]
Kamimura, Yoichiro [1 ]
Devreotes, Peter N. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA
来源：
NATURE CELL BIOLOGY | 2007年 / 9卷 / 01期
关键词：
D O I：
10.1038/ncb0107-15
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P-3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P-3 in directional sensing.
引用
收藏
页码：15 / 17
页数：3
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