Transition metal-free, base-promoted hydroalkoxylation: Synthesis of substituted imidazo[2,1-c][1,4]oxazines

被引:0
|
作者
MUTHUPANDI NAGARAJ
SHANMUGAM MUTHUSUBRAMANIAN
机构
[1] Madurai Kamaraj University,Department of Organic Chemistry, School of Chemistry
来源
关键词
1,4-Oxazines; hydroalkoxylation; 6-; regioselectivity; 1,5-alkynyl alcohol;
D O I
暂无
中图分类号
学科分类号
摘要
An efficient, transition metal-free method to synthesize substituted imidazo[2,1-c][1,4]oxazine derivatives via hydroalkoxylation of 1,5-alkynyl alcohol has been described. The reaction proceeds regioselectively with exclusive formation of 6-exo-dig product.
引用
收藏
页码:451 / 458
页数:7
相关论文
共 50 条
  • [31] SYNTHESIS OF DNA-INTERACTIVE PYRROLO[2,1-C][1,4]BENZODIAZEPINES
    THURSTON, DE
    BOSE, DS
    CHEMICAL REVIEWS, 1994, 94 (02) : 433 - 465
  • [32] SYNTHESIS OF "BENZIMIDAZO(2,1-C)-1,4-BENZDIAZEPIN DERIVATIVES
    IVANOV, EI
    BOGATSKY, AV
    KAMALOV, GL
    BABILINA, TV
    UKRAINSKII KHIMICHESKII ZHURNAL, 1980, 46 (10): : 1076 - 1078
  • [33] The design, synthesis and biological evaluation of a set of C2-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepine dimers
    Howard, P. W.
    Chen, Z.
    Gregson, S. J.
    Stephenson, M.
    Klee, S.
    Hartley, J. M.
    Subur, G.
    Hartley, J. A.
    Thurston, D. E.
    EJC SUPPLEMENTS, 2006, 4 (12): : 95 - 95
  • [34] Base-promoted aerobic oxidative synthesis of fused 1,3,5-triazines under metal-free conditions
    Chen, Jinjin
    Sun, Zhaozhao
    Xiao, Fuhong
    Deng, Guo-Jun
    GREEN CHEMISTRY, 2020, 22 (20) : 6778 - 6782
  • [35] Design, synthesis and biological evaluation of novel C2-aryl-substituted pyrrolo[2,1-c][1,4] benzodiazepine monomers
    Howard, Philip W.
    Antonow, Dyeison
    Cooper, Nectaroula
    Stephenson, Marissa
    Hartley, John A.
    Jenkins, Terence C.
    Thurston, David E.
    CANCER RESEARCH, 2006, 66 (08)
  • [36] Transition Metal-Free Cascade Cyclization of Epoxy-Ynamides: To Go for 1,3-Oxazines or 1,4-Oxazines?
    Kumari, A. Leela Siva
    Reddy, Alla Siva
    Swamy, K. C. Kumara
    ORGANIC LETTERS, 2016, 18 (21) : 5752 - 5755
  • [37] Skeletally Diverse Synthesis of Innovative [2,1-c]-1,4-Oxazepine and [1,4]-Quinoxaline Systems
    Lee, Chia-Hsin
    Wu, Wen-Chun
    Dangate, Prasad S.
    Shen, Li-Ching
    Chung, Wen-Sheng
    Sun, Chung-Ming
    ACS COMBINATORIAL SCIENCE, 2015, 17 (10) : 623 - 630
  • [38] NEW SYNTHESIS OF 4H-PYRROLO[2,1-C][1,4] BENZOXAZINE DERIVATIVES
    ARTICO, M
    DEMARTIN.G
    NACCI, V
    CHEMISTRY & INDUSTRY, 1968, (46) : 1601 - &
  • [39] The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines
    O'Neil, IA
    Thompson, S
    Kalindjian, SB
    Jenkins, TC
    TETRAHEDRON LETTERS, 2003, 44 (42) : 7809 - 7812
  • [40] Base-promoted transition metal-free phosphorylation/acylation of 2-vinyl pyridines with Ph2PCl and carboxylic acids
    Li, Zhichao
    Zong, Lianze
    Hu, Xixi
    Li, Xinjin
    Sun, Feng-Gang
    Dong, Yunhui
    Xu, Zhengbao
    Liu, Hui
    Zhang, Lizhi
    ORGANIC CHEMISTRY FRONTIERS, 2023, 10 (13) : 3264 - 3268