The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM)

被引：0
|
作者：
Hayder M. Al-kuraishy
Ali I. Al-Gareeb
Hebatallah M. Saad
Gaber El-Saber Batiha
机构：
[1] Al-Mustansiriyah University,Department of Pharmacology, Toxicology and Medicine, Medical Faculty, College of Medicine
[2] Matrouh University,Department of Pathology, Faculty of Veterinary Medicine
[3] Damanhour University,Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine
来源：
Inflammopharmacology | 2023年 / 31卷
关键词：
Fibroblast growth factor 21; T2DM; Metformin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a transmembrane co-receptor. In type 2 diabetes mellitus (T2DM), inflammatory disorders stimulate the release of FGF21 to overcome insulin resistance (IR). FGF21 improves insulin sensitivity and glucose homeostasis. Metformin which is used in the management of T2DM may increase FGF21 expression. Accordingly, the objective of this review was to clarify the metformin effect on FGF21 in T2DM. FGF21 level and expression of FGF2Rs are dysregulated in T2DM due to the development of FGF21 resistance. Metformin stimulates the hepatic expression of FGF21/FGF2Rs by different signaling pathways. Besides, metformin improves the expression of β-Klotho which improves FGF21 sensitivity. In conclusion, metformin advances FGF21 signaling and decreases FGF21 resistance in T2DM, and this might be an innovative mechanism for metformin in the enhancement of glucose homeostasis and metabolic disorders in T2DM patients.
引用
收藏
页码：1751 / 1760
页数：9
相关论文
共 50 条
  • [41] Life Expectancy of Individuals with Type 2 Diabetes Mellitus (T2DM) in the United States
    Kianmehr, Hamed
    Yang, Shuang
    Fonseca, Vivian
    Shi, Lizheng
    Brown, Joshua D.
    Guo, Yi
    Shao, Hui
    [J]. DIABETES, 2020, 69
  • [42] Cause of Hospitalizations in Patients with Type 2 Diabetes Mellitus (T2DM) in the CANVAS Program
    Mahaffey, Kenneth W.
    Ianus, Juliana
    Damaraju, C. V.
    Neal, Bruce
    De Zeeuw, Dick
    Fulcher, Greg
    Pfeifer, Michael
    Matthews, David R.
    [J]. DIABETES, 2019, 68
  • [43] The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM)
    Stedman, Mike
    Rea, Rustam
    Duff, Christopher J.
    Livingston, Mark
    McLoughlin, Katie
    Wong, Louise
    Brown, Stephen
    Grady, Katherine
    Gadsby, Roger
    Gibson, John M.
    Paisley, Angela
    Fryer, Anthony A.
    Heald, Adrian H.
    [J]. ENDOCRINOLOGY DIABETES & METABOLISM, 2022, 5 (02)
  • [44] Glycaemic control and pregnancy outcomes in women with Type 2 diabetes mellitus (T2DM)
    Pang, W. H.
    Tan, Z.
    Todd, D.
    Halliday, M.
    Gill, F.
    Rhoads, M.
    Sathiskumar, P.
    Gallagher, A.
    de Chazal, R.
    Lawrence, I. G.
    [J]. DIABETIC MEDICINE, 2008, 25
  • [45] Time To Add-On Medication Use for Patients with Type 2 Diabetes Mellitus (T2DM) Who Failed Metformin Monotherapy
    Qiu, Ying
    Fu, Alex Z.
    Radican, Larry
    [J]. DIABETES, 2010, 59 : A70 - +
  • [46] Adiponectin and vascular stiffness in youth with obesity and type 2 diabetes mellitus (T2DM)
    Gungor, N
    Thompson, T
    Sutton-Tyrrell, K
    Janosky, J
    Arslanian, S
    [J]. DIABETES, 2004, 53 : A68 - A68
  • [47] Epidemiology of Diabetic Nephropathy in Adults with Type 2 Diabetes Mellitus (T2DM) in the US
    Chaudhari, Paresh
    Zhou, Zhou
    Yang, Hongbo
    Fang, Anna
    Wu, Eric
    Seifeldin, Raafat
    [J]. DIABETES, 2016, 65 : A387 - A387
  • [48] Prevention and current onset delay approaches of type 2 diabetes mellitus (T2DM)
    Souto, Selma B.
    Souto, Eliana B.
    Braga, Daniel C.
    Medina, Jose L.
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 67 (07) : 653 - 661
  • [49] Predictors of depressive symptoms in youth at risk for type 2 diabetes mellitus (T2DM)
    Holl, Marita G.
    Jefferson, Vanessa
    Womack, Julie A.
    Grey, Margaret
    [J]. DIABETES, 2006, 55 : A424 - A424
  • [50] MobiDiabet: Mobile Telemonitoring System for Patients with Type 2 Diabetes Mellitus (T2DM)
    Alcala Juarez, Anakaren
    Hernandez Villegas, Manuel Alejandro
    Dominguez, Eduardo Lopez
    Hernandez Velazquez, Yesenia
    Dominguez Isidro, Saul
    Ovando Diego, Liliana
    Hernandez Sanchez, Olivia
    De La Calleja, Jorge
    Pomares Hernandez, Saul Eduardo
    Medina Nieto, Maria Auxilio
    [J]. APPLIED SCIENCES-BASEL, 2020, 10 (22): : 1 - 36
12345