Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

被引：0

作者：

Jie Yin

Kerim Babaoglu

Chad A Brautigam

Lindsay Clark

Zhenhua Shao

Thomas H Scheuermann

Charles M Harrell

Anthony L Gotter

Anthony J Roecker

Christopher J Winrow

John J Renger

Paul J Coleman

Daniel M Rosenbaum

机构：

[1] University of Texas Southwestern Medical Center,Department of Biophysics

[2] Merck Research Laboratories,Department of Structural Chemistry

[3] Merck Research Laboratories,Department of Neuroscience

[4] Merck Research Laboratories,Department of Medicinal Chemistry

来源：

Nature Structural & Molecular Biology | 2016年 / 23卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Human orexin receptors (hOX1R and hOX2R) are GPCRs involved in sleep regulation. Structures of hOX1R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal the basis for subtype selectivity.

引用

页码：293 / 299

页数：6

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