Innervation of the human epidermis. A historical review

被引:0
|
作者
G. Lauria
机构
[1] Department of Neurology,
[2] National Neurologic Institute “ C. Besta”,undefined
[3] Via Celoria 11,undefined
[4] I-20133,undefined
[5] Milano,undefined
[6] Italy,undefined
来源
The Italian Journal of Neurological Sciences | 1999年 / 20卷
关键词
Key words Skin biopsy; Epidermis; Intra-epidermal nerve fibers; Sensory neuropathy; Protein gene product 9.5;
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中图分类号
学科分类号
摘要
Skin biopsy represents an attractive technique to evaluate the extensive innervation of human epidermis, as demonstrated by the immunoreactivity of the intra-epidermal nerve fibers to the marker protein gene product 9.5. Intra-epidermal nerve fibers can be reliably quantified, and their density correlates with both the presence and the severity of sensory neuropathy. The first description of nerve fibers within human epidermis was published by Paul Langerhans. However, the limitations imposed by the relatively insensitive staining methods led several investigators working during the following century to deny or minimize their existence. The author reviews the assumptions and the striking discrepancies emerging from the wide literature on cutaneous sensory terminations since the late nineteenth century and highlights the new developments emerging from the most recent works.
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页码:63 / 70
页数:7
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