Consistent Decrease in Telomere Length in Parathyroid Tumors but Alteration in Telomerase Activity Limited to Malignancies: Preliminary Report

被引：0

作者：

Makoto Kammori

Ken-Ichi Nakamura

Hajime Kanauchi

Takao Obara

Masaki Kawahara

Yoshikazu Mimura

Michio Kaminishi

Kaiyo Takubo

机构：

[1] Department of Surgery,

[2] Endocrine and Metabolic Unit,undefined

[3] The University of Tokyo,undefined

[4] 3-28-6 Mejirodai,undefined

[5] Bunkyo-ku,undefined

[6] Tokyo 112-8688,undefined

[7] Japan,undefined

[8] Department of Clinical Pathology,undefined

[9] Tokyo Metropolitan Institute of Gerontology,undefined

[10] 35-2 Sakaecho,undefined

[11] Itabashi-ku,undefined

[12] Tokyo 173-0015,undefined

[13] Japan,undefined

[14] Department of Endocrine Surgery,undefined

[15] Tokyo Women’s Medical University,undefined

[16] Kawadacho,undefined

[17] Shinjuku-ku,undefined

[18] Tokyo 162-8666,undefined

[19] Japan,undefined

来源：

World Journal of Surgery | 2002年 / 26卷

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摘要：

Telomerase is known to be activated and telomere length altered in various types of malignant and benign tumors, but whether this is also the case for parathyroid lesions has hitherto been unclear. We therefore investigated telomerase activity and telomere length in 3 parathyroid metastatic cancers, 6 adenomas, 2 cases of parathyroid hyperplasia, and 16 samples of normal parathyroid tissue. Telomerase activity, assayed by the telomeric repeat amplification protocol, was detected in all of the parathyroid cancers (100%), in none of the 8 parathyroid benign lesions, and in only 1 of the 16 normal parathyroid samples (8.3%). Telomere length, determined by the terminal restriction fragment assay, was reduced in the tumor tissues with a mean telomere length of 8.23 ± 0.86 kbp compared with the 12.61 ± 0.81 kbp for the 16 age-matched subjects (p = 0.002). The results indicate that telomerase activity and telomere length may reflect the biologic behavior of individual parathyroid lesions.

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页码：1083 / 1087

页数：4

共 22 条

[21] Telomerase Activity, mTert Gene Expression and the Telomere Length in Mouse Mesenchymal Stem Cells in the Late Period after γ- and γ,n-Irradiation and in Tumors Developed from These Cells
O. V. Vysotskaya
A. I. Glukhov
Yu. P. Semochkina
S. A. Gordeev
E. Yu. Moskaleva
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2021, 15 : 80 - 88
[22] Telomerase Activity, mTert Gene Expression and the Telomere Length in Mouse Mesenchymal Stem Cells in the Late Period after γ- and γ,n-Irradiation and in Tumors Developed from These Cells
Vysotskaya, O. V.
Glukhov, A. I.
Semochkina, Yu. P.
Gordeev, S. A.
Moskaleva, E. Yu.
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2021, 15 (01) : 80 - 88

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