The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo

被引：0
|
作者：
Anthony Tumber
Laura S. Collins
Kamille Dumong Petersen
Annemette Thougaard
Sanne J. Christiansen
Marielle Dejligbjerg
Peter Buhl Jensen
Maxwell Sehested
James W. A. Ritchie
机构：
[1] TopoTarget UK LTD,Finsen Centre
[2] TopoTarget A/S,Diagnostic Centre
[3] Symbion Science Park,undefined
[4] Rigshospitalet,undefined
[5] Rigshospitalet,undefined
来源：
Cancer Chemotherapy and Pharmacology | 2007年 / 60卷
关键词：
Histone deacetylase inhibitors; Drug combinations; Synergy; 5-fluorouracil; Colorectal cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：275 / 283
页数：8
相关论文
共 50 条
  • [31] A phase Ib/II study of PXD101 alone and in combination with 5-fluorouracil in patients with advanced solid tumors
    Northfelt, D. W.
    Marschke, R. F., Jr.
    Bonnem, E.
    Ooi, C. E.
    Gerwien, R.
    Hawthorne, T.
    Clarke, A.
    Buhl-Jensen, P.
    Von Hoff, D.
    Grem, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [32] A simple and sensitive high-performance liquid chromatographic method for quantification of PXD101, a histone deacetylase inhibitor in human plasma
    Zhang, Ningning
    Goh, Boon Cher
    Khoo, Yok Moi
    Yeo, Winnie
    Lee, How Sung
    THERAPEUTIC DRUG MONITORING, 2007, 29 (02) : 231 - 235
  • [33] Phase II Study of Belinostat (PXD101), a Histone Deacetylase Inhibitor, for Second Line Therapy of Advanced Malignant Pleural Mesothelioma
    Ramalingam, Suresh S.
    Belani, Chandra. P.
    Ruel, Christopher
    Frankel, Paul
    Gitlitz, Barbara
    Koczywas, Marianna
    Espinoza-Delgado, Igor
    Gandara, David
    JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (01) : 97 - 101
  • [34] Gemigliptin, a novel dipeptidyl peptidase-IV inhibitor, exerts a synergistic cytotoxicity with the histone deacetylase inhibitor PXD101 in thyroid carcinoma cells
    S. H. Kim
    J. G. Kang
    C. S. Kim
    S.-H. Ihm
    M. G. Choi
    H. J. Yoo
    S. J. Lee
    Journal of Endocrinological Investigation, 2018, 41 : 677 - 689
  • [35] Gemigliptin, a novel dipeptidyl peptidase-IV inhibitor, exerts a synergistic cytotoxicity with the histone deacetylase inhibitor PXD101 in thyroid carcinoma cells
    Kim, S. H.
    Kang, J. G.
    Kim, C. S.
    Ihm, S-H
    Choi, M. G.
    Yoo, H. J.
    Lee, S. J.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2018, 41 (06) : 677 - 689
  • [36] A Phase Ib safety and pharmacodynamic study of PXD101 alone and in combination with 5-fluorouracil in patients with advanced solid tumors
    Northfelt, D.
    Ooi, C. E.
    Gerwien, R.
    Hawthorne, T.
    Clarke, A.
    Jones, S.
    Rodriguez, G.
    Buhl-Jensen, P.
    Von Hoff, D.
    Grem, J.
    EJC SUPPLEMENTS, 2006, 4 (12): : 57 - 57
  • [37] In vitro and in vivo antitumor effect of HDAC inhibitor in combination with irinotecan, 5-fluorouracil or oxaliplatin in colon cancer
    Na, Young-Soon
    Kim, Tae Won
    Park, Hyo Suk
    Lee, Jae-Lyun
    Ro, Seonggu
    Kim, Jin Cheon
    Lee, Jung Shin
    Jang, Se Jin
    CANCER RESEARCH, 2009, 69
  • [38] Activity of the histone deacetylase (HDAC) inhibitor PXD101 in preclinical studies and in a phase I study in patients with advanced haematological tumors.
    Gimsing, P
    Wu, F
    Qian, XZ
    Jeffers, M
    Knudsen, L
    Sehested, M
    Lichenstein, HS
    BLOOD, 2005, 106 (11) : 932A - 933A
  • [39] Effects of a novel histone deacetylase inhibitor, PXD101, when used as monotherapy or in combination with bortezomib on tumor growth in mouse models of human multiple myeloma.
    Campbell, Richard A.
    Sanchez, Eric
    Chen, Haiming
    Turker, Lauren
    Trac, Olivia
    Li, Mingjie
    Shalitin, Dror
    Gordon, Melinda S.
    Pang, Shen
    Bonavida, Benjamin
    Said, Jonathan
    Jeffers, Michael
    Qian, Xiaozhong
    Lichenstein, Henri S.
    Berenson, James R.
    BLOOD, 2006, 108 (11) : 993A - 993A
  • [40] Gene expression screen in cell panel selected for varying sensitivity towards the histone deacetylase inhibitor (HDACi) PXD101 reveals potential predictors of HDACi sensitivity
    Dejligbjerg, Marielle
    Christensen, Ib Jarle
    Grauslund, Morten
    Jensen, Peter B.
    Sehested, Maxwell
    APMIS, 2007, 115 (03) : 287 - 287
12345