The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo

被引:0
|
作者
Anthony Tumber
Laura S. Collins
Kamille Dumong Petersen
Annemette Thougaard
Sanne J. Christiansen
Marielle Dejligbjerg
Peter Buhl Jensen
Maxwell Sehested
James W. A. Ritchie
机构
[1] TopoTarget UK LTD,Finsen Centre
[2] TopoTarget A/S,Diagnostic Centre
[3] Symbion Science Park,undefined
[4] Rigshospitalet,undefined
[5] Rigshospitalet,undefined
来源
关键词
Histone deacetylase inhibitors; Drug combinations; Synergy; 5-fluorouracil; Colorectal cancer;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:275 / 283
页数:8
相关论文
共 50 条
  • [1] The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo
    Tumber, Anthony
    Collins, Laura S.
    Dumong Petersen, Kamille
    Thougaard, Annemette
    Christiansen, Sanne J.
    Dejligbjerg, Marielle
    Buhl Jensen, Peter
    Sehested, Maxwell
    Ritchie, James W. A.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2007, 60 (02) : 275 - 283
  • [2] The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
    Buckley, Michael T.
    Yoon, Joanne
    Yee, Herman
    Chiriboga, Luis
    Liebes, Leonard
    Ara, Gulshan
    Qian, Xiaozhong
    Bajorin, Dean F.
    Sun, Tung-Tien
    Wu, Xue-Ru
    Osman, Iman
    JOURNAL OF TRANSLATIONAL MEDICINE, 2007, 5 (1)
  • [3] The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
    Michael T Buckley
    Joanne Yoon
    Herman Yee
    Luis Chiriboga
    Leonard Liebes
    Gulshan Ara
    Xiaozhong Qian
    Dean F Bajorin
    Tung-Tien Sun
    Xue-Ru Wu
    Iman Osman
    Journal of Translational Medicine, 5
  • [4] The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models
    Na, Young-Soon
    Jung, Kyung-Ah
    Kim, Seung-Mi
    Hong, Yong Sang
    Ryu, Min-Hee
    Jang, Se Jin
    Moon, Dae Hyuk
    Cho, Dong-Hyung
    Kim, Jin Cheon
    Lee, Jung Shin
    Kim, Tae Won
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 68 (02) : 389 - 398
  • [5] The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models
    Young-Soon Na
    Kyung-Ah Jung
    Seung-Mi Kim
    Yong Sang Hong
    Min-Hee Ryu
    Se Jin Jang
    Dae Hyuk Moon
    Dong-Hyung Cho
    Jin Cheon Kim
    Jung Shin Lee
    Tae Won Kim
    Cancer Chemotherapy and Pharmacology, 2011, 68 : 389 - 398
  • [6] The histone deacetylase inhibitor PXD101 synergises with established chemotherapeutics to inhibit tumor cell proliferation and upregulate apoptosis in vitro.
    Ritchie, J
    Tumber, A
    Edwards, N
    Finn, P
    Jensen, PB
    Sehested, M
    McLaughlin, F
    CLINICAL CANCER RESEARCH, 2003, 9 (16) : 6105S - 6106S
  • [7] The histone deacetylase inhibitor PXD101 inhibits the growth of human ovarian and colon tumour xenografts in vivo.
    Plumb, JA
    Williams, RJ
    Finn, PW
    Bandara, MJ
    Romero, MR
    Watkins, CJ
    La Thangue, NB
    Brown, R
    BRITISH JOURNAL OF CANCER, 2002, 86 : S16 - S16
  • [8] Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment
    Lin, Shu-Fu
    Lin, Jen-Der
    Chou, Ting-Chao
    Huang, Yu-Yao
    Wong, Richard J.
    PLOS ONE, 2013, 8 (10):
  • [9] Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies
    Qian, Xiaozhong
    LaRochelle, William J.
    Ara, Gulshan
    Wu, Frank
    Petersen, Kamille Dumong
    Thougaard, Annemette
    Sehested, Maxwell
    Lichenstein, Henri S.
    Jeffers, Michael
    MOLECULAR CANCER THERAPEUTICS, 2006, 5 (08) : 2086 - 2095
  • [10] Effect of the histone deacetylase (HDAC) inhibitor PXD101 on the human colon carcinoma cell line FET
    McArdle, Jessica K.
    Brattain, Michael
    Howell, Gillian
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 757 - 757