Modeling human disease in rodents by CRISPR/Cas9 genome editing

被引：0
|
作者：
Marie-Christine Birling
Yann Herault
Guillaume Pavlovic
机构：
[1] University of Strasbourg,CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM
[2] Université de Strasbourg,Institut de Génétique et de Biologie Moléculaire et Cellulaire
[3] Centre National de la Recherche Scientifique,undefined
[4] Institut National de la Santé et de la Recherche Médicale,undefined
[5] Université de Strasbourg,undefined
来源：
Mammalian Genome | 2017年 / 28卷
关键词：
Genome Editing; International Mouse Phenotyping Consortium (IMPC); Non-allelic Homologous Recombination (NAHR); Low Copy Repeats (LCRs); Copy Number Variation (CNVs);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.
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页码：291 / 301
页数：10
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