An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

被引：0
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作者：
Karen I Zeller
Anil G Jegga
Bruce J Aronow
Kathryn A O'Donnell
Chi V Dang
机构：
[1] The Sidney Kimmel Comprehensive Cancer Center,Division of Hematology, Department of Medicine
[2] The Johns Hopkins University School of Medicine,Divisions of Pediatric Informatics and Molecular Developmental Biology
[3] Children's Hospital Research Foundation,Program in Human Genetics and Molecular Biology
[4] Children's Hospital Medical Center and Department of Biomedical Engineering,undefined
[5] University of Cincinnati,undefined
[6] The Johns Hopkins University School of Medicine,undefined
来源：
Genome Biology | / 4卷
关键词：
Chromatin Immunoprecipitation; Putative Target Gene; Phylogenetic Footprinting; Direct Target Gene; DDX18 Gene;
D O I：
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摘要：
We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.
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