An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

被引：411
|
作者：
Zeller, KI
Jegga, AG
Aronow, BJ
O'Donnell, KA
Dang, CV [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Med,Div Hematol, Baltimore, MD 21205 USA
[2] Childrens Hosp, Med Ctr, Childrens Hosp Res Fdn, Div Pediat Informat, Cincinnati, OH 45229 USA
[3] Childrens Hosp, Med Ctr, Childrens Hosp Res Fdn, Div Mol Dev Biol, Cincinnati, OH 45229 USA
[4] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45229 USA
[5] Johns Hopkins Univ, Sch Med, Program Human Genet & Mol Biol, Baltimore, MD 21205 USA
来源：
GENOME BIOLOGY | 2003年 / 4卷 / 10期
关键词：
D O I：
10.1186/gb-2003-4-10-r69
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.
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页数：10
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