Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

被引：0
|
作者：
Sadia Naureen
Shazia Noreen
Areesha Nazeer
Muhammad Ashraf
Umber Alam
Munawar Ali Munawar
Misbahul Ain Khan
机构：
[1] University of the Punjab,Institute of Chemistry
[2] The Islamia University of Bahawalpur,Department of Chemistry
[3] The Islamia University of Bahawalpur,Department of Biochemistry and Biotechnology
来源：
Medicinal Chemistry Research | 2015年 / 24卷
关键词：
Multicomponent reactions; Benzil; Fisher indole synthesis; NMR spectra;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a–2u) were synthesized and evaluated for their α-glucosidase inhibition. The new compounds showed significant α-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, 1H NMR, 13C NMR, and elemental analyses.
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页码：1586 / 1595
页数：9
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