Cell-free chromatin: A newly described mediator of systemic inflammation

被引：0
|
作者：
Shahid Chaudhary
Indraneel Mittra
机构：
[1] Tata Memorial Centre,Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer
来源：
Journal of Biosciences | 2019年 / 44卷
关键词：
H2AX; cell-free chromatin; double strand DNA breaks; inflammation; NF; B; systemic inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent research has shown that cell-free chromatin (cfCh) particles that are released from the billions of cells that die in the body everyday can enter into healthy cells, integrate into their genomes and induce dsDNA breaks and apoptotic responses. Genomic integration of cfCh activates NFκB suggesting a novel mechanism of induction of systemic inflammation. Since DNA damage and inflammation are underlying pathologies in multiple devastating acute and chronic disease conditions, the discovery of agents that can inactivate cfCh may provide therapeutic possibilities.
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