Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

被引：0

作者：

Tohru Ishitani

Tomoko Hirao

Maho Suzuki

Miho Isoda

Shizuka Ishitani

Kenichi Harigaya

Motoo Kitagawa

Kunihiro Matsumoto

Motoyuki Itoh

机构：

[1] Unit on Nervous Development Systems,Division of Biological Science

[2] Group of Signal Transduction,Division of Cell Regulation Systems, Department of Post

[3] Laboratory of Cell Regulation,Genome Science Center

[4] Graduate School of Science,Department of Molecular and Tumor Pathology

[5] Institute for Advanced Research,undefined

[6] Nagoya University,undefined

[7] Medical Institute of Bioregulation,undefined

[8] Kyushu University,undefined

[9] Chiba University Graduate School of Medicine,undefined

来源：

Nature Cell Biology | 2010年 / 12卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Notch-mediated transcriptional activation requires the formation of a ternary complex, consisting of NotchICD, CSL and a Mastermind family member. Nemo-like kinase is shown to negatively regulate Notch signalling and to promote neurogenesis in zebrafish by phosphoprylating Notch1ICD and reducing formation of the ternary complex.

引用

页码：278 / 285

页数：7

共 19 条

[1] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex
Ishitani, Tohru
Hirao, Tomoko
Suzuki, Maho
Isoda, Miho
Ishitani, Shizuka
Harigaya, Kenichi
Kitagawa, Motoo
Matsumoto, Kunihiro
Itoh, Motoyuki
NATURE CELL BIOLOGY, 2010, 12 (03) : 278 - U84
[2] Nemo-like kinase promotes neurogenesis by interfering with formation of Notch transcription complex
Ishitani, Tohru
Hirao, Tomoko
Suzuki, Maho
Isoda, Miho
Ishitani, Shizuka
Kitagawa, Motoo
Matsumoto, Kunihiro
Itoh, Motoyuki
NEUROSCIENCE RESEARCH, 2010, 68 : E90 - E90
[3] Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo
Rottinger, Eric
Croce, Jenifer
Lhomond, Guy
Besnardeau, Lydia
Gache, Christian
Lepage, Thierry
DEVELOPMENT, 2006, 133 (21): : 4341 - 4353
[4] Nemo-like kinase inhibits androgen receptor transcriptional activity in prostate cancer cells
Emami, Katayoonn H.
Brown, Lisha G.
Pitts, Tiffany E. M.
Brubaker, Kristen D.
Corey, Eva
CANCER RESEARCH, 2006, 66 (08)
[5] Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-κB
Yasuda, J
Yokoo, H
Yamada, T
Kitabayashi, I
Sekiya, T
Ichikawa, H
CANCER SCIENCE, 2004, 95 (01) : 52 - 57
[6] Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis
Wilkes, Mark C.
Shibuya, Aya
Liu, Y. Lucy
Mark, Kailen
Mercado, Jaqueline
Saxena, Mallika
Sathianathen, Ryan S.
Kim, Hye Na
Glader, Bertil
Kenny, Paraic
Sakamoto, Kathleen M.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 300 (08)
[7] Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators
Kitagawa, Motoo
JOURNAL OF BIOCHEMISTRY, 2016, 159 (03): : 287 - 294
[8] Lentivirus-delivered nemo-like kinase small interfering RNA inhibits laryngeal cancer cell proliferation in vitro
Tai, Jun
Rao, Yuansheng
Fang, Jugao
Huang, Zhigang
Yu, Zhenkun
Chen, Xiaohong
Zhou, Weiguo
Xiao, Xiao
Long, Ting
Han, Yang
Liu, Qiaoyin
Li, Aidong
Ni, Xin
MOLECULAR MEDICINE REPORTS, 2015, 12 (04) : 5619 - 5624
[9] Nemo-Like Kinase, an Essential Effector of Anterior Formation, Functions Downstream of p38 Mitogen-Activated Protein Kinase
Ohnishi, Eriko
Goto, Toshiyasu
Sato, Atsushi
Kim, Mi-sun
Iemura, Shun-ichiro
Ishitani, Tohru
Natsume, Tohru
Ohnishi, Junji
Shibuya, Hiroshi
MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (03) : 675 - 683
[10] Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in xenopus development
Satoh, Kiyotoshi
Ohnishi, Junji
Sato, Atsushi
Takeyama, Michio
Iemura, Shun-Ichiro
Natsume, Tohru
Shibuya, Hiroshi
MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (21) : 7623 - 7630

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