Notch signalling in the nucleus: roles of Mastermind-like (MAML) transcriptional coactivators

被引：76
|
作者：
Kitagawa, Motoo [1 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Mol & Tumor Pathol, Chou Ku, 1-8-1 Inohana, Chiba 2608670, Japan
来源：
JOURNAL OF BIOCHEMISTRY | 2016年 / 159卷 / 03期
关键词：
MAML; Mastermind; Notch signalling; signal transduction; transcription; DROSOPHILA-MELANOGASTER; LYMPHOCYTE DEVELOPMENT; MAMMALIAN NOTCH; CELL-SURVIVAL; HUMAN HOMOLOG; IN-VIVO; PATHWAY; COMPLEX; GENE; ACTIVATION;
D O I：
10.1093/jb/mvv123
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Notch signalling plays pivotal roles in development and homeostasis of all metazoan species. Notch is a receptor molecule that directly translates information of cell-cell contact to gene expression in the nucleus. Mastermind is a conserved and essential nuclear factor that supports the activity of Notch. Here, the past and current studies of the interplay between these factors are reviewed.
引用
收藏
页码：287 / 294
页数：8
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