New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

被引：0
|
作者：
Ayechew Adera Getu
Abiye Tigabu
Ming Zhou
Jianrong Lu
Øystein Fodstad
Ming Tan
机构：
[1] Institute of Biochemistry and Molecular Biology,Department of Physiology, School of Medicine, College of Medicine and Health Sciences
[2] Institute of Biomedical Sciences,Department of Biochemistry and Molecular Biology, College of Medicine
[3] and Research Center for Cancer Biology,undefined
[4] China Medical University,undefined
[5] University of Gondar,undefined
[6] Cancer Research Institute and School of Basic Medical Sciences,undefined
[7] Central South University,undefined
[8] University of Florida,undefined
[9] Department of Tumor Biology,undefined
[10] Institute for Cancer Research,undefined
[11] Oslo University Hospital Radiumhospitalet,undefined
来源：
Molecular Cancer | / 22卷
关键词：
B7-H3; CD276; Cancer; Immunotherapy; Drug Development;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. In addition to its immune checkpoint function, B7-H3 has been linked to tumor cell proliferation, metastasis, and therapeutic resistance. Furthermore, its drastic difference in protein expression levels between normal and tumor tissues suggests that targeting B7-H3 with drugs would lead to cancer-specific toxicity, minimizing harm to healthy cells. These properties make B7-H3 a promising target for cancer therapy.
引用
收藏
相关论文
共 50 条
  • [31] Targeting B7-H3 (CD276) in neuroblastoma: In vitro evaluation of Fc-optimized antibodies and immunocytokines
    Heubach, Florian
    Schlegel, Patrick
    Zekri, Latifa
    Manz, Timo
    Schleicher, Sabine
    Rabsteyn, Armin
    Jung, Gundram
    Buehring, Hans-Joerg
    Gillies, Stephen D.
    Handgretinger, Rupert
    Lang, Peter
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (02)
  • [32] Regulation of Immune Checkpoint Antigen CD276 (B7-H3) on Human Placenta-Derived Mesenchymal Stromal Cells in GMP-Compliant Cell Culture Media
    Amend, Bastian
    Buttgereit, Lea
    Abruzzese, Tanja
    Harland, Niklas
    Abele, Harald
    Jakubowski, Peter
    Stenzl, Arnulf
    Gorodetsky, Raphael
    Aicher, Wilhelm K.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (22)
  • [33] A Platform for Extracellular Interactome Discovery Identifies Novel Functional Binding Partners for the Immune Receptors B7-H3/CD276 and PVR/CD155
    Husain, Bushra
    Ramani, Sree R.
    Chiang, Eugene
    Lehoux, Isabelle
    Paduchuri, Sairupa
    Arena, Tia A.
    Patel, Ashka
    Wilson, Blair
    Chan, Pamela
    Franke, Yvonne
    Wong, Athena W.
    Lill, Jennie R.
    Turley, Shannon J.
    Gonzalez, Lino C.
    Grogan, Jane L.
    Martinez-Martin, Nadia
    MOLECULAR & CELLULAR PROTEOMICS, 2019, 18 (11) : 2310 - 2323
  • [34] A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155
    Husain, B.
    Martinez-Martin, N.
    ANNALS OF ONCOLOGY, 2019, 30 : 37 - 37
  • [35] Pan-Cancer Interrogation of B7-H3 (CD276) as an Actionable Therapeutic Target Across Human Malignancies
    Miller, Carly D.
    Lozada, John R.
    Zorko, Nicholas A.
    Elliott, Andrew
    Makovec, Allison
    Radovich, Milan
    Heath, Elisabeth I.
    Agarwal, Neeraj
    Mckay, Rana R.
    Garje, Rohan
    Bastos, Bruno R.
    Hoon, Dave S. B.
    Orme, Jacob J.
    Sartor, Oliver
    VanderWalde, Ari
    Nabhan, Chadi
    Sledge, George
    Shenderov, Eugene
    Dehm, Scott M.
    Lou, Emil
    Miller, Jeffrey S.
    Hwang, Justin H.
    Antonarakis, Emmanuel S.
    CANCER RESEARCH COMMUNICATIONS, 2024, 4 (05): : 1369 - 1379
  • [36] CD276 (B7-H3) Maintains Proliferation and Regulates Differentiation in Angiogenic Function in Late Endothelial Progenitor Cells
    Son, YeonSung
    Kwon, Sang-Mo
    Cho, Je-Yoel
    STEM CELLS, 2019, 37 (03) : 382 - 394
  • [37] Comprehensive Analysis Reveals Distinct Immunological and Prognostic Characteristics of CD276/B7-H3 in Pan-Cancer
    Ding, Jinye
    Sun, Yaoqi
    Sulaiman, Zubaidan
    Li, Caixia
    Cheng, Zhongping
    Liu, Shupeng
    INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2023, 16 : 367 - 391
  • [38] B7-H3/CD276 Inhibitors: Is There Room for the Treatment of Metastatic Non-Small Cell Lung Cancer?
    Malapelle, Umberto
    Parente, Paola
    Pepe, Francesco
    Di Micco, Martina Concetta
    Russo, Alessandro
    Clemente, Celeste
    Graziano, Paolo
    Rossi, Antonio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (24)
  • [39] A Dual-Payload Antibody-Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer
    Zhou, Zhuoxin
    Si, Yingnan
    Zhang, Jiashuai
    Chen, Kai
    George, Ashley
    Kim, Seulhee
    Zhou, Lufang
    Liu, Xiaoguang
    CANCER RESEARCH, 2024, 84 (22) : 3848 - 3863
  • [40] Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
    Liu, Xianglei
    Zhelev, Doncho
    Adams, Cynthia
    Chen, Chuan
    Mellors, John W.
    Dimitrov, Dimiter S.
    TRANSLATIONAL ONCOLOGY, 2021, 14 (12):
12345