Intimate details of the most poisonous poison

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作者
Bal Ram Singh
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[1] University of Massachusetts Dartmouth,the Department of Chemistry and Biochemistry
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摘要
Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal that minimal structural changes occur upon binding a ganglioside or after substrate cleavage. The unique structure of this toxin provides information for developing preventive measures against botulism.
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页码:617 / 619
页数:2
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