A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures

被引：0
|
作者：
Hong Wang
Matthias Eberstadt
Edward T. Olejniczak
Robert P. Meadows
Stephen W. Fesik
机构：
[1] Abbott Laboratories,
来源：
Journal of Biomolecular NMR | 1998年 / 12卷
关键词：
bicelle; lipid; liquid crystal; protein alignment; residual dipolar coupling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A mixture of dilauroyl phosphatidylcholine (DLPC) and 3-(cholamidopropyl)dimethylammonio-2-hydroxyl-1-propane sulfonate (CHAPSO) in water forms disc shaped bicelles that become ordered at high magnetic fields over a wide range of temperatures. As illustrated for the FK506 binding protein (FKBP), large residual dipolar couplings can be measured for proteins dissolved in low concentrations (5% w/v) of a DLPC/CHAPSO medium at a molar ratio of 4.2:1. This system is especially useful for measuring residual dipolar couplings for molecules that are only stable at low temperatures.
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页码：443 / 446
页数：3
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