What can be learned from the history of recurrence in migraine? A comment

被引:0
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作者
Peer Tfelt-Hansen
机构
[1] Glostrup Hospital,Danish Headache Centre, Department of Neurology
[2] University of Copenhagen,undefined
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关键词
Triptans; Recurrence; Ergotamine;
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摘要
Recurrence was first recognised as a clinical problem in 1989 with the advent of sumatriptan. The history of recurrence in early sumatriptan randomised clinical trials is described. Recurrence has been ascribed to patient-dependent factors but experience with ergot alkaloids suggested that recurrence can also be treatment-dependent. Possible mechanisms for recurrence are discussed.
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页码:311 / 315
页数:4
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