A two-step mechanism for TRF2-mediated chromosome-end protection

被引：0
|
作者：
Keiji Okamoto
Cristina Bartocci
Iliana Ouzounov
Jolene K. Diedrich
John R. Yates III
Eros Lazzerini Denchi
机构：
[1] Laboratory of Chromosome Biology and Genomic Stability,Department of Molecular and Experimental Medicine
[2] The Scripps Research Institute,Department of Chemical Physiology and Cell Biology
[3] The Scripps Research Institute,undefined
来源：
Nature | 2013年 / 494卷
关键词：
D O I：
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中图分类号：
学科分类号：
摘要：
The telomere-biding protein TRF2 is shown to protect telomeres from activating the DNA-damage response through two mechanisms: preventing the activation ATM kinase through its dimerization domain, in addition to independently suppressing signalling events occurring downstream of ATM.
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页码：502 / 505
页数：3
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