Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells

被引：0
|
作者：
Gakuro Harada
Shiori Onoue
Chisato Inoue
Sakae Hanada
Yoshinori Katakura
机构：
[1] Kyushu University,Graduate School of Systems Life Sciences
[2] Kyushu University,Graduate School of Bioresource and Bioenvironmental Sciences
[3] Kyushu University,Faculty of Agriculture
来源：
Cytotechnology | 2018年 / 70卷
关键词：
Delphinidin; Senescence; Lipid; HepG2; SMARCD1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Delphinidin is an anthocyanidin commonly found in various fruits and vegetables. Delphinidin has been known to possess many functions, such as an antioxidant, and anti-inflammatory, anti-cancer and anti-muscular atrophy agent. In this study, we attempted to evaluate the effects of delphinidin on lipid accumulation in hepatocytes. The results showed that palmitic acid (PA)-induced cellular senescence in HepG2 cells and reduced the expression of SMARCD1, which is known to regulate senescence-associated lipid accumulation in hepatocytes. However, delphinidin-3-glucoside (D3 g) suppressed PA-induced senescence and reversed the expression of SMARCD1 to the level of untreated HepG2 cells. Consequently, D3 g inhibited PA-induced lipid accumulation through the restoration of the expression of SMARCD1 and fatty acid oxidation genes. Taken together, our results suggest that D3 g suppresses the lipid accumulation induced by hepatocyte senescence.
引用
收藏
页码：1707 / 1712
页数：5
相关论文
共 50 条
  • [1] Delphinidin-3-glucoside suppresses lipid accumulation in HepG2 cells
    Harada, Gakuro
    Onoue, Shiori
    Inoue, Chisato
    Hanada, Sakae
    Katakura, Yoshinori
    CYTOTECHNOLOGY, 2018, 70 (06) : 1707 - 1712
  • [2] Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway
    Yang, Xiaohong
    Luo, En
    Liu, Xin
    Han, Bin
    Yu, Xiaoping
    Peng, Xiaoli
    BMC CANCER, 2016, 16
  • [3] Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway
    Xiaohong Yang
    En Luo
    Xin Liu
    Bin Han
    Xiaoping Yu
    Xiaoli Peng
    BMC Cancer, 16
  • [4] Dual effect of capsaicin on lipid accumulation in HepG2 cells
    Bort, A. C.
    Morell, M. C.
    Ramos-Torres, A.
    Diaz-Laviada, I.
    Rodriguez-Henche, N.
    FEBS JOURNAL, 2015, 282 : 373 - 374
  • [5] ACTION OF PHYTOCHEMICALS ON LIPID ACCUMULATION AND LIPOTOXICITY IN HEPG2 CELLS
    Sathyanarayana, Nanditha
    Asimba, Viola
    Clarke, Garry
    Fry, Jeffrey
    ATHEROSCLEROSIS, 2012, 223 (02) : 534 - 534
  • [6] Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells
    Lee, Seung-Cheol
    Jee, Seung-Cheol
    Kim, Min
    Kim, Soee
    Shin, Min Kyoung
    Kim, Yunkyung
    Sung, Jung-Suk
    ANTIOXIDANTS, 2021, 10 (08)
  • [7] Oxymatrine attenuates lipid accumulation in HepG2 cells by inducing autophagy
    Li, Yang
    Zhang, Pu
    Ren, Luping
    Song, Guangyao
    Chen, Xinwei
    Yu, Xiaolei
    Yang, Liying
    Chen, Shuchun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 12 (04): : 3449 - 3457
  • [8] Effects of an anthocyanin (delphinidin-3-glucoside) from wild blueberries on the proangiogenic and prothrombotic properties of endothelial cells
    Bonacina, G.
    Marchetti, M.
    Vignoli, A.
    Diani, E.
    Porrini, M.
    Falanga, A.
    THROMBOSIS RESEARCH, 2010, 125 : S189 - S189
  • [9] Oxymatrine attenuates lipid accumulation in HepG2 cells by inducing autophagy
    Zhang, Pu
    Ren, Luping
    Li, Yang
    Song, Guangyao
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2016, 32 (SUPP 2) : 57 - 57
  • [10] The anthocyanin delphinidin-3-glucoside, contained in wild blueberries, protects endothelial cells from proangiogenic and prothrombotic stimuli
    Marchetti, M.
    Bonacina, G.
    Diani, E.
    Vignoli, A.
    Riso, P.
    Porrini, M.
    Falanga, A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 : 246 - 246
12345