Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

被引：0
|
作者：
Yi-Fan Lin
Anna M. Schulz
Mark W. Pellegrino
Yun Lu
Shai Shaham
Cole M. Haynes
机构：
[1] Cell Biology Program,
[2] Memorial Sloan Kettering Cancer Center,undefined
[3] Laboratory of Developmental Genetics,undefined
[4] The Rockefeller University,undefined
[5] BCMB Allied Program,undefined
[6] Weill Cornell Medical College,undefined
来源：
Nature | 2016年 / 533卷
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摘要：
In the context of mitochondrial genome heteroplasmy that causes defective oxidative phosphorylation in C. elegans, the ATFS-1-mediated mitochondrial unfolded protein response maintains the deleterious mitochondrial DNA in an attempt to recover oxidative phosphorylation activity and avoid cellular dysfunction.
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页码：416 / 419
页数：3
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