The Molecular Mechanisms of Mitochondrial Unfolded Protein Response

被引：0
|
作者：
Fan Yu-Mei [1 ]
Hao Qiang [1 ]
Liu Si-Ying [1 ]
Chang Yan-Zhong [1 ]
Duan Xiang-Lin [1 ]
Tan Ke [1 ]
机构：
[1] Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Shijiazhuang 050024, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 44卷 / 06期
关键词：
mitochondria; mitochondrial unfolded protein response; ATFS-1; HSF1; ATF5; diseases; METABOLIC DYSFUNCTION; STRESS-RESPONSE; LIFE-SPAN; UPR; ACTIVATION; LONGEVITY; GENE; DISEASE; CELLS; BETA;
D O I：
10.16476/j.pibb.2016.0385
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As newly found cellular stress response, the mitochondrial unfolded protein response (UPRmt) is associated with the pathological process of aging, cancer and neurodegenerative diseases. To maintain mitochondrial protein homeostasis, cell will inspire UPRmt program by activating the transcription of mitochondrial chaperones and proteases encoded by nuclear DNA. Exploring the mechanisms of UPRmt is essential for understanding the pathological process of aging and mitochondria-related diseases. In this review, we focus on various inducers of UPRmt, the different mechanisms of UPRmt, the regulatory factors, and relationship with aging, immunity and other diseases in C. elegans and mammalian cells to provide new theoretical basis and therapeutic target for these diseases.
引用
收藏
页码：477 / 485
页数：9
相关论文
共 58 条
  • [1] Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans
    Bennett, Christopher F.
    Wende, Helen Vander
    Simko, Marissa
    Klum, Shannon
    Barfield, Sarah
    Choi, Haeri
    Pineda, Victor V.
    Kaeberlein, Matt
    [J]. NATURE COMMUNICATIONS, 2014, 5
  • [2] Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis
    Berendzen, Kristen M.
    Durieux, Jenni
    Shao, Li-Wa
    Tian, Ye
    Kim, Hyun-eui
    Wolff, Suzanne
    Liu, Ying
    Dillin, Andrew
    [J]. CELL, 2016, 166 (06) : 1553 - +
  • [3] Mitochondrial function controls intestinal epithelial stemness and proliferation
    Berger, Emanuel
    Rath, Eva
    Yuan, Detian
    Waldschmitt, Nadine
    Khaloian, Sevana
    Allgaeuer, Michael
    Staszewski, Ori
    Lobner, Elena M.
    Schoettl, Theresa
    Giesbertz, Pieter
    Coleman, Olivia I.
    Prinz, Marco
    Weber, Achim
    Gerhard, Markus
    Klingenspor, Martin
    Janssen, Klaus-Peter
    Heikenwalder, Mathias
    Haller, Dirk
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [4] Mitochondrial Aβ:: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
    Caspersen, C
    Wang, N
    Yao, J
    Sosunov, A
    Chen, X
    Lustbader, JW
    Xu, HW
    Stern, D
    McKhann, G
    Yan, SD
    [J]. FASEB JOURNAL, 2005, 19 (12): : 2040 - +
  • [5] Mitochondrial disease and endocrine dysfunction
    Chow, Jasmine
    Rahman, Joyeeta
    Achermann, John C.
    Dattani, Mehul T.
    Rahman, Shamima
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2017, 13 (02) : 92 - 104
  • [6] Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster
    de Castro, Pimenta
    Costa, A. C.
    Lam, D.
    Tufi, R.
    Fedele, V.
    Moisoi, N.
    Dinsdale, D.
    Deas, E.
    Loh, S. H. Y.
    Martins, L. M.
    [J]. CELL DEATH AND DIFFERENTIATION, 2012, 19 (08): : 1308 - 1316
  • [7] Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart
    Dogan, Sukru Anil
    Pujol, Claire
    Maiti, Priyanka
    Kukat, Alexandra
    Wang, Shuaiyu
    Hermans, Steffen
    Senft, Katharina
    Wibom, Rolf
    Rugarli, Elena I.
    Trifunovic, Aleksandra
    [J]. CELL METABOLISM, 2014, 19 (03) : 458 - 469
  • [8] The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
    Durieux, Jenni
    Wolff, Suzanne
    Dillin, Andrew
    [J]. CELL, 2011, 144 (01) : 79 - 91
  • [9] The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR
    Fiorese, Christopher J.
    Schulz, Anna M.
    Lin, Yi-Fan
    Rosin, Nadine
    Pellegrino, Mark W.
    Haynes, Cole M.
    [J]. CURRENT BIOLOGY, 2016, 26 (15) : 2037 - 2043
  • [10] Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models
    Fujimoto, M
    Takaki, E
    Hayashi, T
    Kitaura, Y
    Tanaka, Y
    Inouye, S
    Nakai, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (41) : 34908 - 34916
123456